Gabriel E. Soto, MD, PHD

SPECIALTIES: Cardiology, Electrophysiology, Heart Failure, Interventional Cardiology

Accepting First Option

Appointments & Locations

About Gabriel Soto


Heart and Vascular


Cardiology, Electrophysiology, Heart Failure, Interventional Cardiology


Heart and Vascular

Office Locations

371 South Broadview Street
Cape Girardeau, MO 63703    Maps & Directions
Phone: 573-331-6710
2002 Kanell Boulevard
Poplar Bluff, MO 63901    Maps & Directions
Phone: 573-331-6710
Office Hours: Third Wednesday of every month - 10:00 AM – 2:00 PM



  • American Board of Internal Medicine: Cardiovascular Disease
  • American Board of Internal Medicine: Clinical Cardiac Electrophysiology
  • National Board of Physicians and Surgeons
    Specialty - Internal Medicine
    Subspecialties - Cardiovascular Disease, Electrophysiology


  • 1992, Wesleyan University, BA
  • 2000, Washington University School of Medicine, PhD
  • 1996, Washington University School of Medicine, MD


  • 2003, Internal Medicine, Barnes-Jewish Hospital & Washington University School of Medicine


  • 2007, Barnes-Jewish Hospital & Washington University School of Medicine
  • 2008, Barnes-Jewish Hospital & Washington University School of Medicine

Professional Affiliations

  • American Heart Association
  • American College of Cardiology
  • Heart Rhythm Society



  • Rising Star Award in Cardiovascular Research: Washington University
  • Steven L. Dresler Award: Washington University
  • David F. Silbert Outstanding Teaching Assistant Award: Washington University
  • Award for Excellence in Physical Diagnosis - Finalist: ACP
  • National Research Service Award: NIH-NJGMS
  • Departmental High Honors in Chemistry: Wesleyan University
  • Sehlinger Prize for Academic Achievement • Wesleyan University
  • Hawk Prize in Biochemistry: Wesleyan University
  • Silverman Prize in General Chemistry: Wesleyan University
  • CRC Award in Organic Chemistry: CRC Press


Publications & Research

  • Soto GE, Spertus JA (2007). EPOCH and ePRISM: A Web-Based Translational Framework for Bridging Outcomes Research and Clinical Practice. Computers in Cardiology, 34, 205-208.
  • Ahmad H, Decker C, Olabiyi 0, Soto GE, Spertus JA (2007). Patient Recall of Complications and their Risk Based on Method of Informed Consent: Original Consent Form versus the PREDICT (Patient Refined Expectations for Deciding Invasive Cardiac Treatments) Tool. Circulation, I 16, 3508:11-794.
  • Kosiborod M, Soto GE, Jones PG, Krumholz HM, Weintraub WS, Deedwania P, Spertus JA (2007). Identifying Heart Failure Patients at High-Risk for Near-Term Cardiovascular Events Using Serial Health Status Assessments. Circulation, 115, 1975-1981.
  • Decker CJ, Ahmad H, Soto GE, Kosiborod M, Reid KJ, Jones PG, Spertus JA (2007). Patient Refined Expectations Deciding Invasive Cardiac Treatment (PREDICT). Journal of the American College of Cardiology, 49, 286A.
  • Soto GE, Jones P, Zhang Z, Weintraub WS, Spertus JA (2005). Health Status as a Predictor of Costs of Caring for Patients with Heart Failure. Circulation, 111, e34 I.
  • Soto GE, Decker C, Jones P, Reid K, Nugent K, Shipman A, TessendorfT, Vance C, Spertus JA (2005). PRISM Update: Experiences in Using a Web-based Framework for the Deployment of Predictive Clinical Models at the Point of Care. Circulation, 111, e34 I. Soto GE, Jones P, Spertus JA (2004). PRISM: A Web-based Framework for Deploying Predictive Clinical Models. Computers in Cardiology, 31, 193-196.
  • Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA (2004). Value of Health Status in Patients with Heart Failure Following Acute Myocardial Infarction. Circulation, 110, 546-551.
  • Soto GE, Jones P, Weintraub WS, Krumholz HM, Spertus JA (2004). Using Health Status to Identify Heart Failure Patients at High Risk for Future Cardiovascular Events. Circulation, 109, e255.
  • Soto GE, Jones P, Decker CJ, Agarwal D, Zhang J, Medhi D, Spertus JA (2004). PRISM: A Novel Tool for Deploying Predictive Clinical Models. Circulation, 109, e24 I.
  • Spertus JA, Soto GE, Jones P, Krumholz HM (2003). Health Status is an Independent Predictor of Cardiovascular Death and Hospitalization in Patients with Heart Failure. Circulation, 108, IV- 600.
  • Hultgren SJ, Almqvist F, Soto GE. (2002). Washington University. β-Lactam-like Chaperone Inhibitors. United States Patent 6,495,539.
  • Barnhart MM, Pinkner JS, Soto GE, Sauer FG, Langermann S, Waksman G, Frieden C, Hultgren SJ. (2000). PapD-like chaperones provide the missing information for folding of pilin proteins. Proceedings of the National Academia qfScience USA, 97, 7709-7714.
  • Mulvey MA, Dodson KW, Soto GE, Hultgren SJ. (2000). Fimbria, Pili. In Encyclopedia of Microbiology (r' Edition). Edited by Lederberg. New York: Academic Press, pp.361-379.
  • Soto GE, Hultgren SJ. (1999). Bacterial Adhesins: Common Themes and Variations in Architecture and Assembly. Journal of Bacteriology, 181, I 059-1071.
  • Soto GE, Hultgren SJ. ( 1999). Assembly of bacterial adhesins across the outer membrane via the chaperone-usher pathway. In Transport of Molecules Across Microbial Membranes (58th Symposium of the Society for General Microbiology), pp. 124-137. Edited by Broome-Smith JK, Baumberg S, Stirling CJ, Ward FB. Cambridge: Cambridge University Press.
  • Soto GE, Dodson KW, Ogg D, Liu C, Heuser J, Knight S, Kihlberg J, Jones CH, Hultgren SJ. ( 1998). Periplasmic Chaperone Recognition Motif of Subunits Mediates Quaternary Interactions in the Pilus. EMBO.Journal, 17, 6155-6167.
  • Bullitt E, Jones CH, Striker R, Soto G, Jacob-Dubuisson F, Pinkner J, Wick MJ, Makowski L, Hultgren SJ. ( 1996). Development of Pilus Organelle Sub-Assemblies In Vitro Depends on Chaperone Uncapping of a Beta Zipper. Proceedings c?f the National Academia of Science USA, 93, 12890-12895.
  • Soto GE, Zhu Z, Evelhoch JL, Ackerman JJ. (1996). Tumor 31 P NMR pH Measurements in Vivo: A comparison of Inorganic Phosphate and Intracellular 2-Deoxyglucose-6-Phosphate as pHnmr Indicators in Murine Radiation-Induced Fibrosarcoma-1. Magnetic Resonance in Medicine, 36, 698-704.
  • Ackerman JJ, Soto GE, Spees WM, Zhu Z, Evelhoch JL. (1996). The NMR Chemical Shift pH Measurement Revisited: Analysis of Error and Modeling of a pH Dependent Reference. Magnetic Resonance in Medicine, 36, 674-683.
  • Xu Y, Soto G, Hirsch KR, Pratt RF. (1996). Kinetics and mechanism of the hydrolysis of depsipeptides catalyzed by the β-lactamase of Enterobacter cloacae P99. Biochemistry, 35, 3595-3603.
  • Xu Y, Soto G, Adachi H, van der Linden MPG, Keck W, Pratt RF. (1994). Relative specificities of a series of β-lactam-recognizing enzymes towards the side-chains of penicillins and of acyclic thioldepsipeptides. Biochemistry .Journal, 302, 851-856.