About Benjamin Yan


Dr. Benjamin Yan, MD, PhD, is an exceptionally trained Radiation Oncologist at the Southeast Cancer Center. Before joining the SoutheastHEALTH cancer care team, Dr. Yan served as Medical Director of Radiation Oncology at Ozarks Medical Center in West Plains, MO.

Dr. Yan chose to specialize in Radiation Oncology “because I am committed to helping my patients while they fight a devastating disease. I am humbled to be able to make a positive difference in their lives.”

Dr. Yan and his wife chose to call Cape Girardeau home because of its great schools, family outdoor activities and a Division 1 basketball team (go, Redhawks!). When Dr. Yan is not with patients, he enjoys basketball, fishing hunting and the great outdoors.




Radiation Oncology



Office Locations

789 South Mount Auburn Road
Cape Girardeau, MO 63703    Maps & Directions
Phone: 573-519-4700



  • American Board of Radiology in Radiation Oncology


  • 2005, Duke University, PhD
  • 2001, Loma Linda University, MS
  • 1998, Peking Union Medical College, MD


  • 2010, Radiation Oncology, Virginia Commonwealth University Medical Center

Professional Affiliations

  • The Radiosurgery Society (RSS)
  • American Society of Clinical Oncology (ASCO)
  • American Society of Therapeutic Radiation Oncology (ASTRO)
  • American Association of Cancer Research (AACR)
  • American Medical Association (AMA)
  • Radiation Research Society (RRS)


Publications & Research

  • Yan B, Ouyang R, Huang C, Liu F, Neill D, Li C, Dewhirst M. Heat induces gene amplification in cancer cells. Biochem Biophys Res Commun. 2012 Oct 26;427(3):473-7
  • Kon T, Zhang X, Huang Q, Yang Z, Liu S, Yan B, Li F, Wang H, Li CY. Oncolytic virus­ mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA. Transl Cancer Res 2012 Jun;1(2):4-14
  • Yan B, Neill DM, Liu T, Dewhirst MW. 42 and 44C Heat exposure induces gene amplification in Colorectal cancer HCTl 16 cells. International Journal of Radiation Oncology * Biology * Physics 2011 October 1; Vol. 81, Issue 2, Supplement, Page S701
  • Moghanaki D, Koontz B, Karlin J, Mukhopadhyay N, Yan B, Hagan M, Anscher M. Improved Biochemical Complete Response (BCR) and Biochemical Relapse-free Survival (RFS) with Whole Pelvis (WPRT) vs. Prostate Bed (PBRT) Radiotherapy in Patients Undergoing Salvage Treatment following Prostatectomy. International Journal of Radiation Oncology * Biology * Physics 2010 November 1; Vol. 78, Issue 3, Supplement, Pages S30-S31
  • Yan B, Wang H, Xie D, Wakamatsu N, Anscher MS, Dewhirst MW, Mitchel RE, Chen BJ, Li CY. Increased skin carcinogenesis in caspase-activated Dnase knockout mice. Carcinogenesis. 2009 Oct;30(10): 1776-80.
  • Ma Q, Cavallin LE, Yan B, Zhu S, Duran EM, Wang H, Hale LP, Dong C, Cesarman E, Mesri EA, Goldschmidt-Clermont PJ. Antitumorigenicity of antioxidants in a transgenic Rael model of Kaposi's sarcoma. Proc NatlAcad Sci USA 2009 May 26;106(21):8683-8.
    7fi    Yan B, Peng Y, Li CY. Molecular analysis of genetic instability caused by chronic inflammation. (Book Chapter 20) Methods M ol Biol. 2009;512: 15-28. The Humana Press Inc. Publisher
  • Zhu S, Evans S, Yan B, Povsic TJ, Tapson V, Goldschmidt-Clermont PJ, Dong C. Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. Circulation. 2008 Nov 18;118(21):2156-65.
  • Wang H, Yan B, Satterwhite LL, Ma Q, Goldschmidt-Clermont PJ. Increased activity of phosphatase PP2A in the presence of the PlA2 polymorphism of alphaIIbbeta3. Biochem Biophys Res Commun. 2008 Feb 29;367(1):72-7.
  • Yan B, Wang H, Rabbani ZN, Dewhirst MW, Li CY. TNF□ is a potent endogenous mutagen that promotes cellular transformation. Journal o(Clinical Oncology. 2007 Vol 25, No 18S (June 20): 21104
  • Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q, Vujaskovic Z, Dewhirst MW, Li CY. Regulation of HIF-1 through S-nitrosylation during radiation therapy. Molecular Cell. 2007 Apr 13;26(1 ):63-74.
  • Yan B, Wang H, Peng Y, Hu Y, Wang H, Zhang X, Chen Q, Bedford JS, Dewhirst MW, Li CY. A unique role of DNA fragmentation factor in maintaining genomic stability. Proc Natl Acad Sci USA. 2006 Jan 31;103(5):1504-9.
  • Yan B, Wang H, Wang H, Zhuo D, Li F, Kon T, Dewhirst M, Li CY. Inhibition of apoptotic DNA fragmentation results in increased chromosomal instability in a P53-independent manner. Oncogene. 2006 Aug 31;25(39):5370-6.
  • Yan B, Wang H, Rabbani ZN, Zhao Y, Li W, Yuan Y, Li F, Dewhirst MW, Li CY. TNF□ is a potent endogenous mutagen that promotes cellular transformation by inducing reactive oxygen species. Cancer Research 2006 Dec 15;66: 11565-11570
  • Yan B, Wang H, Li F, Li CY. Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. British Journal of Cancer. 2006 Dec 18;95(12):1696-700.
  • Yan B, Wang H, Bedford JS, Dewhirst MW, Li CY. A novel role of DNA fragmentation factor as a tumor suppressor through maintaining genetic stability. Journal of Clinical Oncology, Vol 24, No. 18S (June 20 Supplement), 2006: 10023
  • Huang Q, Zhang X, Wang H, Yan B, Kirkpatrick J, Dewhrist MW, Li CY. A novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clinical Cancer Research. 2004 Feb 15;10(4):1439-45
  • Yan B, Wang H, Kon T, Li CY. Pim-1 kinase inhibits activation of the reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection. Braz J Med Biol Res. 2006 Feb;39(2): 169-76.
  • Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M. The Pim-2 kinase phosphorylates BAD on serine-I 12 and reverses BAD-induced cell death. Journal of Biological Chemistry 2003 Nov 14;278( 46):45358-67
  • Zhang X, Li Y, Huang Q, Wang H, Yan B, Dewhirst MW, Li CY. Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. Clinical Cancer Research. 2003 Mar; 9(3):1155-60.
  • Duan ZJ, Zhu J, Yan B, Hou YD. Isolation and characterization of anti-TNF peptides from phage-displayed CDR-based peptide library. Chinese Journal of Biochemistry and Molecular Biology. 2003 Oct; 19(5):547-551.
  • Yan B, Zemskova M, Lilly MB et al. The pim-2 Serine kinase phosphorylates the proapoptotic protein BAD on Serine-112 and opposes BAD-induced cell death, Blood. 2002 Nov. 16; 100(11) part 1:738
  • Wang H, Yan B, Goldschmidt-Clermont PJ et al. Changes in expression profiling resulting from alphaIIbbeta3 and its polymorphism suggest a role in apoptosis and differentiation of hematopoietic cells, Blood. 2002 Nov. 16; 100(11) part 2: 168b
  • Yan B, Lilly MB, Li CY et al. The anti-apoptotic effect of Pim-1 kinase is not through regulation of MAP kinase pathway, Molecular Targets for Cancer Therapy: Second Biennial Meeting Conference Syllabus, 2002 October 11-15
  • Xu H, Yang Q, Tang B, Yan B. A clinical analysis of 94 cases of recurrent stroke, BULL. OF HUNAN MED. UNIV. 1998; 23(1): 85-92.
  • Xu H, Yang Q, Tang B, Yan B. The study of the relationship between anticardiolipin antibodies and cerebrovascular diseases, Journal of Cerebral and Nervous Diseases. 1997; 5(6):331- 333.
  • Yan B, Cheng Y. Detection by in situ hybridization of HIV and c-myc RN A in tumor cells of AIDS-related B-cell lymphomas, Foreign Medicine in Physiology and Pathology. 1993; 13( 4): 219.